For many centuries improving the resolution of light microscopy meant perfecting lenses and other optical elements, a strategy whose limits became evident with the discovery of the diffraction barrier in 1873. From there onwards, it was well accepted that the resolution of any light-focusing microscope is limited by the wavelength of light in use. At the turn of this century, the diffraction barrier was radically overcome, and it became clear that lens-based fluorescence microscopes can resolve features down to the molecular scale.
At its most fundamental level, this breakthrough in resolution is based on the fact that tiny features in the sample are no longer discerned by the focusing of light. Rather the feature molecules or molecular tags are prompted to briefly assume two different states (e.g. fluorescence on/off) so that they become distinguishable when illuminated by the same diffraction pattern.
Thus, in modern superresolution microscopy – in short, “nanoscopy” – fluorescent molecular tags have to fulfill a double role. Not only do they have to highlight the features of interest, but they also have to provide the (pair of) states required for separation. Therefore, it is the symbiosis of molecular tags and optical design that makes the microscopes of today sharp and bright.
This conference brings together experts in fluorescence and labeling with those designing and applying new concepts of far-field optical nanoscopy.
MIT, Cambridge, USA
Yale University, New Haven, USA
Columbia University, New York, USA
Friedrich-Schiller-University Jena, Jena, GER
University of New South Wales, Sydney, AUS
University of North Carolina, Chapel Hill, USA
MPI for Biophysical Chemistry / MPI for Medical Research, Göttingen/Heidelberg, GER
University of California, San Francisco, USA
Yale University, New Haven, USA
University Medical Faculty / MPI for Biophysical Chemistry, Göttingen, GER
MPI for Medical Research, Heidelberg, GER
Utrecht University, Utrecht, NL
Technical University Wien, Wien, A
Additional speakers will be selected based on submitted abstracts.
This is the preliminary schedule. We will update the schedule in due time before the conference starts!
12:30 - 01:45 pm
02:10 pm
"Mapping the inner world of cells"
02:15 pm - 02:50 pm
"Nuclear pores as universal reference standards for quantitative microscopy"
02:55 pm - 03:10 pm
"3D Nanoscopy at 10,000 Cells a Day"
03:15 pm - 03:30 pm
"T cell receptor clustering – a mechanism of signal transduction"
03:35 pm - 04:10 pm
04:15 pm - 05:45 pm
"Nanobodies reveal an extra-synaptic population of SNAP-25 and Syntaxin 1A in hippocampal neurons"
05:45 pm - 06:00 pm
"Zooming into Golgi biology with super-resolution imaging"
06:05 pm - 06:20 pm
"Using light to dissect and direct transport inside neurons"
06:25 pm - 07:00 pm
"Fluorescent and Bioluminescent Sensor Proteins"
09:00 am - 09:35 am
"Dissecting the Single-Cell Dynamics of Xist RNA in X Chromosome Inactivation by 3D Super-resolution Microscopy"
09:40 am - 09:55 am
"At a single plane - Airyscan with 2D Superresolution mode"
10:00 am - 10:20 am
10:25 am - 10:45 am
10:50 am - 11:25 am
"Superresolution Microscopy Images: What they tell us about protein clusters – and what they don’t"
11:30 am - 12:05 pm
"Fluorogenic Probes for Bioorthogonal Chemistry – Application in Live-Cell Imaging"
12:10 am - 12:25 pm
"Walking and watching your cells - optogenetics/biosensors to trace live cell circuitry"
12:30 pm - 01:05 pm
01:10 pm - 02:40 pm
"Focusing on mitochondria"
02:45 pm - 03:20 pm
"Use of fluorescent lipid analogs and mysteries in plasma membrane organisation – a super-resolution study"
03:25 pm - 04:00 pm
04:05 pm - 05:35 pm
"TMP-Tag: A Chemical Surrogate to the Fluorescent Proteins for Live Cell Imaging"
05:40 pm - 06:15 pm
"Illuminating the self-assembly of alpha-synuclein amyloid fibrils"
06:20 pm - 06:35 pm
"Euro-BioImaging: Europe’s Research Infrastructure for Imaging Technologies"
06:40 pm - 06:55 pm
ca. 07:10 pm Bus transfer to restaurant in Old Heidelberg Downtown
"3D Multicolor and Live-cell Super-resolution Microscopy for Cell Biological Research"
09:00 am - 09:35 am
"RNA imaging based study of the Dengue and Zika virus replication organelle"
09:40 am - 09:55 am
"Super-resolution microscopy with DNA molecules: Towards localizomics"
10:00 am - 10:15 am
"Optoacoustics – use of rsFPs beyond fluorescence"
10:20 am - 10:35 am
10:40 am - 11:40 am
"Expansion Microscopy"
11:45 am - 12:45 pm
12:50 pm - 01:50 pm
"Fluorescent dyes for super-resolution STED microscopy in living cells"
01:55 pm - 02:10 pm
"A quantitative map of Condensins on mitotic chromatids suggests a three-step hierarchical loop model for mitotic chromosome compaction"
02:15 pm - 02:30 pm
"A MINimum for Maximum Resolution"
02:35 pm - 03:10 pm
ca. 03:15 pm
EARLY BIRD registration (before June 30th) is 195€ for PhDs and 280€ for postdocs and senior researchers. After June 30th (late registration), the fee is 295€ for PhDs and 380€ for postdocs and senior researchers.
Conference attendance as well as lunch and snacks / drinks during the coffee breaks and poster sessions are included in the fee. It also INCLUDES the conference dinner!
The registration process will take you to the registration site of the DKFZ Heidelberg. All necessary information for abstract submission and application for a presentation is provided there. Based on these submissions, the selected candidates will be asked to present their work in a talk.
After submission, confirmation of registration and payment instructions will be provided by email. Please be informed that payment is by bank transfer ONLY. Unfortunately, payments with credit cards or PayPal will not be accepted. Do not hesitate to contact us if you have any other inquiries.
Update mid-October: Registration is still possible, including on-site at the registration desk, but please note that participation at Tuesday night's conference dinner may be limited beyond this point due to limited space at the venue in the Old Town. Thank you for your understanding.
As Heidelberg is a very popular destination for travelers and tourists from all over the world, make
sure to book your accommodation well in advance. There are a lot of hotels available that cover a
huge price range (from affordable to high class).
Please note that we do not specifically recommend any hotels. Hotels within a reasonable
distance to the conference venue in Neuenheimer Feld include the following:
The following web pages provide some additional information about accommodation and also about public transport in Heidelberg:
German Cancer Research Center
Communication Center/ Lecture Hall & Foyer
Im Neuenheimer Feld 280
69120 Heidelberg
Germany
The Heidelberg Neuenheimer Feld Campus is reached via a major bridge over the Neckar river (Mittermaierstr./Jahnstr./Berliner Str.), with just 10-15 minutes of walking
north from the Heidelberg main train station (Hauptbahnhof). The German Cancer Research Center is directly served by bus line 32, which runs frequently.
Additional information on travelling to the DKFZ can be found HERE.
If you need further information about the conference, the payment, the registration or if you have any
other question do not hesitate to contact us!
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MPI for Biophysical Chemistry / MPI for Medical Research, Göttingen/Heidelberg, GER
Senior Editor, Nature Biotechnology
University Medical Faculty / MPI for Biophysical Chemistry, Göttingen, GER
MPI for Biophysical Chemistry, Göttingen, GER
